{"id": "BYHbKPMHyi4", "uploader": "UiO Realfagsbiblioteket", "uploader_id": "realfagsbiblioteket", "uploader_url": "http://www.youtube.com/user/realfagsbiblioteket", "channel_id": "UCynaukrA8wxvJOcyFQJN3Jg", "channel_url": "http://www.youtube.com/channel/UCynaukrA8wxvJOcyFQJN3Jg", "upload_date": "20181025", "license": null, "creator": null, "title": "BIO-torsdag: Enhancere - genregulering p\u00e5 lang avstand", "alt_title": null, "thumbnail": "https://i.ytimg.com/vi/BYHbKPMHyi4/hqdefault.jpg", "description": "Foredrag ved Rein Aasland, instituttleder ved Institutt for biovitenskap.\n\nGenomet dekodes i to hovedtrinn. Det andre trinnet, som ble klarlagt allerede p\u00e5 60-tallet, skjer ved ribosomenes translasjon av informasjon i mRNA til proteinsekvens, ved hjelp av den genetiske koden. Vi vet langt mindre om det f\u00f8rste trinnet, som er transkripsjon fra DNA til mRNA. Hvor skal RNA polymerase begynne og slutte? N\u00e5r skal den begynne og hvor lenge skal den holde p\u00e5? I hvilke celler skal det skje? Svaret p\u00e5 disse sp\u00f8rsm\u00e5lene er genregulering.\n\nEt gen reguleres av transkripsjonsfaktorer som binder til segmenter i DNA, i og rundt en promoter. Men mange gener reguleres ogs\u00e5 p\u00e5 lang avstand ved segmenter i DNA, som er kjent som enhancere. Hvordan g\u00e5r det til at en enhancer som kan ligge tusenvis av basepar borte fra promoterer, kan ha en avgj\u00f8rende rolle i hvorvidt gener er av eller p\u00e5?\n\nhttps://www.ub.uio.no/kurs-arrangement/arrangementer/ureal/2018/181025BioTorsdag.html", "categories": ["Science & Technology"], "tags": ["Rein Aasland"], "subtitles": {}, "automatic_captions": {}, "duration": 2836, "age_limit": 0, "annotations": null, "chapters": null, "webpage_url": "https://www.youtube.com/watch?v=BYHbKPMHyi4", "view_count": 126, "like_count": 2, "dislike_count": 0, "average_rating": 5.0, "formats": [{"format_id": "249", "url": "https://r4---sn-ovgq0oxu-5goe.googlevideo.com/videoplayback?expire=1546834434&clen=17729029&mime=audio%2Fwebm&pl=40&key=yt6&source=youtube&dur=2836.281&lmt=1542834102040231&txp=7201222&c=WEB&id=o-ACKeEzsgsfqzUUuxdpgmn5hU1vCgzhuA6oS5Y2no04qr&gcr=no&ip=2001%3A700%3A100%3A118%3A%3A26&requiressl=yes&gir=yes&signature=8495AD27C817B8D3CDE34571BC4166A8BEAAFF5F.892DF600C2454E362221AD6155CF96DA00A0202D&fvip=2&ipbits=0&sparams=clen%2Cdur%2Cei%2Cgcr%2Cgir%2Cid%2Cip%2Cipbits%2Citag%2Ckeepalive%2Clmt%2Cmime%2Cmm%2Cmn%2Cms%2Cmv%2Cpl%2Crequiressl%2Csource%2Cexpire&mt=1546812272&mv=u&ei=on0yXPK4JNrO7gSvp7WgBg&itag=249&ms=au%2Crdu&mm=31%2C29&mn=sn-ovgq0oxu-5goe%2Csn-5go7yn7s&keepalive=yes&ratebypass=yes", "player_url": "/yts/jsbin/player_ias-vflWb9AD2/en_US/base.js", "ext": "webm", "format_note": "DASH audio", "acodec": "opus", "abr": 50, "filesize": 17729029, "tbr": 51.448, "quality": -1, "vcodec": "none", "downloader_options": {"http_chunk_size": 10485760}, "format": "249 - audio only (DASH audio)", "protocol": "https", "http_headers": {"User-Agent": "Mozilla/5.0 (X11; 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